@misc{10481/105760,
year = {2025},
month = {2},
url = {https://hdl.handle.net/10481/105760},
abstract = {Numerous studies have previously demonstrated the antimicrobial activity of
plant extracts rich in procyanidins. However, these investigations that focused on uncharacterized extracts do not provide information on the structure–activity relationships of
these compounds. The aim of this work was to investigate the antibacterial and antibiofilm
properties of 27 phenolics with coumarin, naphthoquinone and pyranone moieties against
foodborne microorganisms, as well as to establish structure–activity relationships. Minimal
inhibitory concentrations (MICs) for each compound were investigated, as well as their
ability for inhibiting biofilm formation as well as disrupting previously formed biofilms
by food pathogens. Our compounds show high antibacterial and antibiofilm activities
against Gram-positive bacteria. Regarding the structure–activity relationships observed,
the coumarin moiety seems to favor the antibacterial activity against both S. aureus strains
assayed, while a naphthoquinone moiety enhances antibacterial effects against B. cereus.
Moreover, the replacement of OH groups in the B-ring by methoxy groups impairs antibacterial activity of the compounds against target bacteria, while the presence of Cl or OH
groups in the molecules seems to enhance the inhibition of biofilm formation as well as
the disruption of preformed biofilms. These results may be of great relevance for the food
sector, increasing the options of additives that can be used industrially.},
organization = {Consejería de Economía y Conocimiento - Andalucía (FEDER program 2014–2020: grant number 1380669)},
publisher = {MDPI},
keywords = {procyanidin analogs},
keywords = {antibacterial activity},
keywords = {antibiofilm activity},
keywords = {coumarin},
keywords = {naphthoquinone},
keywords = {foodborne bacteria},
title = {Evaluation of Antibacterial and Antibiofilm Properties of Phenolics with Coumarin, Naphthoquinone and Pyranone Moieties Against Foodborne Microorganisms},
doi = {10.3390/molecules30040944},
author = {Alejo-Armijo, Alejandra and Cobo Molinos, Antonio and Alejo Armijo, Alfonso and Altarejos, Joaquín and Salido, Sofía and Ortega-Morente, Elena},
}