@misc{10481/105347,
year = {2025},
month = {5},
url = {https://hdl.handle.net/10481/105347},
abstract = {Childhood obesity has become a major public health concern world
wide, and increasing attention is being paid to the potential role of endocrine-disrupting
 chemicals such as parabens. Understanding environmental contributors is essential for
 early prevention strategies. Objectives: The aim of the present research was to determine
 the presence of parabens in hair samples and to examine its association with excess weight
 AcademicEditor: AndreaVania
 Received: 31March2025
 Revised: 30April2025
 Accepted: 2May2025
 Published: 6 May2025
 Citation: Gálvez-Ontiveros, Y.;
 González-Palacios, P.; Ramírez, V.;
 Monteagudo,C.;Samaniego-Sánchez,
 C.; Rivas, A.; Zafra-Gómez, A.Hairas
 anIndicator of ProlongedParaben
 ExposureandItsRelationtoWeight
 GaininaSampleofSpanishChildren:
 AProof-of-ConceptStudy. Nutrients
 2025, 17, 1593. https://doi.org/
 10.3390/nu17091593
 Copyright: ©2025bytheauthors.
 Licensee MDPI,Basel,Switzerland.
 This article is an open access article
 distributed under the termsand
 conditions of the Creative Commons
 Attribution (CC BY)license
 (https://creativecommons.org/
 licenses/by/4.0/).
 and obesity in a sample of Spanish schoolchildren. Methods: A total of 104 cases and
 166 controls (3–12 year olds) were recruited. Sociodemographic and lifestyle data and
 hair and urine samples were gathered. UHPLC-MS/MS coupled to a triple quadrupole
 detector was used for the quantitative determination of six parabens (methylparaben
 [MetPB], ethylparaben [EthPB], butylparaben [ButPB], propylparaben [PropPB], and iso
propylparaben [i-PropPB]). The relationship between the concentration of parabens in hair
 and urine was examined according to Spearman correlation coefficients. Finally, binary
 logistic regression models were constructed to evaluate the relationship of parabens with
 excess weight/obesity. Results: Detected paraben levels were higher in cases. A weak
 correlation was produced between hair and urine concentrations, with the exception of
 i-PropP (hair)/PropPB (urine) and i-PropP (hair)/i-PropPB (urine) in boys, and i-PropPB
 (hair)/PropPB (urine) in girls. A high level of PropPB was associated with a 4.67 times
 greater risk of excess weight/obesity only in the boys. Conclusions: In males, a high
 concentration of PropPB in hair is associated with excess weight and obesity},
publisher = {MDPI},
title = {Hair as an Indicator of Prolonged Paraben Exposure and Its  Relation to Weight Gain in a Sample of Spanish Children:  AProof-of-Concept Study},
doi = {10.3390/nu17091593},
author = {Gálvez-Ontiveros, Yolanda and González-Palacios, Patricia and Ramírez, Viviana and Monteagudo, Celia and Samaniego-Sánchez, Cristina and Rivas, Ana and Zafra-Gómez, Alberto},
}