@misc{10481/104902,
year = {2024},
month = {8},
url = {https://hdl.handle.net/10481/104902},
abstract = {Introduction: Patients with coronary artery disease (CAD) have a higher risk of developing cognitive impairment and mental health disorders compared to the general population. Physical exercise might improve their brain health. The overall goal of the HEART-BRAIN randomized controlled trial (RCT) is to investigate the effects of different types of exercise on brain health outcomes in patients with CAD, and the underlying mechanisms.

Methods: This three-arm, single-blinded RCT will include 90 patients with CAD (50–75 years). Participants will be randomized into: (1) control group—usual care (n = 30), (2) aerobic high-intensity interval training (HIIT) (n = 30), or (3) HIIT combined with resistance exercise training (n = 30). The 12-week intervention includes 3 supervised sessions (45-min each) per week for the exercise groups. Outcomes will be assessed at baseline and post-intervention. The primary outcome is to determine changes in cerebral blood flow assessed by magnetic resonance imaging. Secondary outcomes include changes in brain vascularization, cognitive measures (i.e., general cognition, executive function and episodic memory), and cardiorespiratory fitness. Additional health-related outcomes, and several potential mediators and moderators will be investigated (i.e., brain structure and function, cardiovascular and brain-based biomarkers, hemodynamics, physical function, body composition, mental health, and lifestyle behavior).

Conclusion: The HEART-BRAIN RCT will provide novel insights on how exercise can impact brain health in patients with CAD and the potential mechanisms explaining the heart-brain connection, such as changes in cerebral blood flow. The results may have important clinical implications by increasing the evidence on the effectiveness of exercise-based strategies to delay cognitive decline in this high-risk population.},
organization = {MCIN/AEI/10.13039/501100011033  PID2020-120249RB-I00, RYC2019-027287-I, PID2022-137399OB-I00},
organization = {Andalusian Government P20_00124, POSTDOC_21_00745},
organization = {CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN)},
organization = {Instituto de Salud Carlos III},
organization = {European Union’s Horizon 2020, Marie Skłodowska-Curie 101064851},
organization = {ESF Investing in your future},
organization = {Spanish Ministry of Science, Innovation and Universities (JDC2022-049642-I), (FPU 22/02476, FPU 21/06192 and FPU 22/03052), (BG22/00075)},
organization = {Swedish Heart-Lung Foundation (grant number 20230343)},
organization = {County Council of Ostergotland, Sweden (grant number RÖ-990967)},
organization = {Swedish Society of Cardiology and the Swedish Society of Clinical Physiology},
organization = {FSE+},
organization = {National Agency for Research and Development (ANID)/Scholarship Program/DOCTORADO BECAS CHILE/2022-(Grant N°72220164)},
organization = {Society of Behavioral Medicine},
organization = {University of Granada},
publisher = {Frontiers},
keywords = {Ischemic disease},
keywords = {Coronary heart disease},
keywords = {Cerebral blood flow},
title = {Exercise and brain health in patients with coronary artery disease: study protocol for the HEART-BRAIN randomized controlled trial},
doi = {10.3389/fnagi.2024.1437567},
author = {Toval Sánchez, José Ángel and Solís Urra, Patricio and Bakker, Esmée A. and Sánchez-Aranda, Lucía and Fernández‐Ortega, Javier and Prieto Lara, Carlos and Alonso-Cuenca, Rosa M. and González García, Alberto and Martín-Fuentes, Isabel and Fernández-Gámez, Beatriz and Olvera-Rojas, Marcos and Coca-Pulido, Andrea and Bellón Fernández, Darío and Sclafani, Alessandro and Sanchez-Martínez, Javier and Rivera-López, Ricardo and Herrera-Gómez, Norberto and Peñafiel-Burkhardt, Rafael and López-Espinosa, Víctor and Corpas-Pérez, Sara and García-Ortega, María Belén and Vega-Cordoba, Alejandro and Barranco-Moreno, Emilio J. and Morales-Navarro, Francisco J. and Nieves, Raúl and Caro-Rus, Alfredo and Amaro Gahete, Francisco José and Mora González, José Rafael and Vidal-Almela, Sol and Carlén, Anna and Miguelez, Jairo H. and Erickson, Kirk I. and Moreno-Escobar, Eduardo and García-Orta, Rocío and Esteban Cornejo, Irene and Ortega Porcel, Francisco Bartolomé},
}