@misc{10481/104726,
year = {2025},
month = {5},
url = {https://hdl.handle.net/10481/104726},
abstract = {Background:
Current treatment of depression is hindered by the delayed onset of the action of antidepressant drugs, often resulting in treatment failure. Therefore, new therapeutic solutions are imperative.
Methodology:
Venlafaxine-loaded poly(lactic-co-glycolic acid) nanoparticles were produced by a double emulsion-solvent evaporation method. Cellular safety assessment and internalization assays were carried out in vitro in human olfactory neuroepithelium cells. The antidepressant effect of intranasal (nose-to-brain) nanoparticle administration was assessed in animals submitted to an animal model of depression by behavioral tests, including open-field, sucrose preference test and tail suspension test.
Results:
The drug entrapment efficiency (55–65 %), particle size (190–210 nm), polydispersity index (<0.2), and zeta potential (−20 mV) of Venlafaxine-loaded poly(lactic-co-glycolic acid) nanoparticles were determined to be adequate. Nanoparticles did not show cytotoxic effects. Cell viability was more than 90 % for all formulations and concentrations assayed. The results of the quantitative and qualitative cell uptake assays were consistent, showing an evident internalization of the nanoparticles into the cells. Furthermore, venlafaxine-loaded nanoparticles administered for just 7 days were able to reverse the phenotype induced by a depressive-like model, showing a significant antidepressant-like effect compared to those treated with free venlafaxine.
Conclusions:
These findings indicated that intranasal venlafaxine-loaded poly(lactic-coglycolic acid) nanoparticles could become a viable technique for improving venlafaxine brain uptake via nose-to-brain. It could also be a promising nanoplatform for enhancing the treatment of depression.},
organization = {Junta de Andalucía (2021/CTS-480; 2019/CTS-480)},
publisher = {Elsevier},
keywords = {Venlafaxine},
keywords = {Nose-to-brain},
keywords = {PLGA nanoparticles},
keywords = {Depression},
title = {Venlafaxine-PLGA nanoparticles provide a fast onset of action in an animal model of depression via nose-to-brain},
doi = {10.1016/j.ijpharm.2025.125692},
author = {Cayero-Otero, María Dolores and Perez-Caballero, Laura and Suarez-Pereira, Irene and Hidalgo-Figueroa, María and Delgado-Sequera, Alejandra and Montesinos, Juan Manuel and Berrocoso, Esther and Martín-Banderas, Lucia},
}