@misc{10481/104298,
year = {2025},
month = {4},
url = {https://hdl.handle.net/10481/104298},
abstract = {Objective: To examine the effects of 24-week moderate (MOD-EX) and vigorous-intensity concurrent training (VIG-EX) on bone parameters and plasma levels of osteoglycin and sclerostin and their interplay with body composition and cardiometabolic risk factors in young, sedentary men and women.
Design: Secondary study from the ACTIBATE randomized controlled trial (ClinicalTrials.gov ID: NCT02365129).
Methods: This study was performed at the Sport and Health University Research Institute and the Virgen de las Nieves University Hospital of the University of Granada. Bone parameters were measured by dual-energy X-ray absorptiometry, and osteoglycin and sclerostin levels, by enzyme-linked immunosorbent assay.
Results: 145 young sedentary adults were assigned to a control (CON, n = 54), a MOD-EX (n = 48), or a VIG-EX (n = 43). 106 participants were included in the per-protocol analyses (CON, n = 42; MOD-EX, n = 33; and VIG-EX, n = 31). After 24 weeks of concurrent training, we observed no differences in changes in bone parameters (all P time × group ≥ .300), osteoglycin (P time × group = .250), and sclerostin levels (P time × group = .489). Moreover, we found no correlations between osteoglycin and sclerostin levels with body composition (all P ≥ .639) and cardiometabolic risk factors (all P ≥ .119).
Conclusion: 24 weeks of concurrent training did not alter bone parameters, and plasma levels of osteoglycin and sclerostin in young, sedentary adults. Moreover, osteoglycin and sclerostin are not related with bone parameters and cardiometabolic risk factors in this population. These findings suggest that longer concurrent training interventions may be needed to enhance bone parameters in young, sedentary adults.},
organization = {Spanish Ministry of Economy and Competitiveness via the Fondo de Investigación Sanitaria del Instituto de Salud Carlos III (PI13/01393)},
organization = {Retos de la Sociedad (DEP2016-79512-R) and European Regional Development Funds (ERDF)},
organization = {Fundación Iberoamericana de Nutrición (FINUT)},
organization = {Redes Temáticas de Investigación Cooperativa RETIC (Red SAMID RD16/0022)},
organization = {AstraZeneca HealthCare Foundation},
organization = {University of Granada Plan Propio de Investigación Excellence actions: Unit of Excellence on Exercise Nutrition and Health (UCEES)},
organization = {Spanish Ministry of Science, Innovation and Universities (FPU22/01631)},
organization = {University of Granada Plan Propio de Investigación (Programa Perfeccionamiento Doctores)},
organization = {Sara Borrell contract (CD23/00231) from the MCIN/ISCIII},
publisher = {Oxford University Press},
keywords = {Bone remodeling},
keywords = {Resistance training},
keywords = {Endurance training},
keywords = {Cardiometabolic health},
keywords = {Glucose metabolism},
title = {Impact of 24-week concurrent training on bone parameters and plasma levels of osteoglycin and sclerostin in young, sedentary adults: secondary analyses from the ACTIBATE randomized controlled trial},
doi = {https://doi.org/10.1093/ejendo/lvaf087},
author = {Martín-Olmedo, Juan J. and Jurado Fasoli, Lucas and Osuna Prieto, Francisco Javier and García Fontana, Cristina and García Fontana, Beatriz and Gracia-Marco, Luis and Muñoz Torres, Manuel Eduardo and Ruiz Ruiz, Jonatan},
}