@misc{10481/103976,
year = {2025},
month = {3},
url = {https://hdl.handle.net/10481/103976},
abstract = {Gene expression (GE) and alternative splicing (AS) contribute to the formation of new interaction networks with potentially significant cellular functions. Here, we investigate ageing in the Drosophila female germline stem cell (GSC) niche and describe functional changes in both GE and AS. The GSC niche comprises three types of support cells, whose ageing transcriptomes reveal differential GE and AS variations related to cell adhesion, cytoskeleton and neural signalling. Because each population show distinctive GE and AS changes, niche cell types possess unique ageing signatures. Depending on the cell population, groups of genes display changes in both GE and AS, revealing a coordinated regulation of transcription and splicing during niche ageing. One such gene is Fasciclin 2, a neural adhesion molecule that we find is essential for niche functioning. Furthermore, genes involved in AS undergo changes in GE and/or AS themselves, providing a mechanistic explanation for the coordination of these two processes during niche ageing. This is the case of the splicing factor Smu1, described here as a key element necessary for ovarian niche homeostasis.},
organization = {MICIU/AEI/10.13039/501100011033 PID2020-115040GB-I00, PID2021-125480NB-I00 and CEX2020-001088-M},
organization = {Junta de Andalucía   P20_00888},
organization = {ERDF, EU},
organization = {MECD  (FPU15/06664), (FPU17/03230)},
publisher = {Springer Nature},
title = {Drosophila ovarian stem cell niche ageing involves coordinated changes in transcription and alternative splicing},
doi = {10.1038/s41467-025-57901-8},
author = {Even-Ros, Dilamm and Huertas-Romero, Judit and Marín-Menguiano, Miriam and Nusspaumer, Gretel and Borge, Miguel and Irimia, Manuel and Zurita Martínez, Federico and González Reyes, Acaimo},
}