@misc{10481/103646,
year = {2025},
month = {4},
url = {https://hdl.handle.net/10481/103646},
abstract = {Progressive multifocal leukoencephalopathy (PML) results from the reactivation
of John Cunningham virus JC virus and is a rare complication of anti-CD20 drug
therapy. Neurofilament light chains increasingly serve as a marker of neuroaxonal
damage in the follow-up of patients with multiple sclerosis (MS), but its role in the
monitoring and detection of processes such as PML is yet to be defined. We
report the case of a patient with MS who was treated with ocrelizumab and
developed PML. Results: Serum neurofilament light chain (sNFL) levels were
elevated at the diagnosis and progressively increased over his follow-up. Our
results suggest that the monitoring of sNFL levels may be useful for the early
diagnosis of PML in patients with MS.},
publisher = {Frontiers},
title = {Case Report: Neurofilament light chain in the follow up of progressive multifocal leukoencephalopathy in a patient with multiple sclerosis treated with ocrelizumab},
doi = {10.3389/fphar.2025.1571699},
author = {Piñar Morales, Raquel and Calle Calle, Raquel and Carrasco García, María and Dávila Arias, Cristina and Villar Guimerans, María Luisa and Barrero Hernández, Francisco Javier},
}