@misc{10481/103262,
year = {2025},
month = {2},
url = {https://hdl.handle.net/10481/103262},
abstract = {Background: The aim of this study was to evaluate the serological response after the complete hepatitis B vaccination of patients according to the immunosuppressive treatment they underwent, and to identify potential factors associated with non-responders. Methods: A prospective cohort study was conducted, and patients under immunosuppressive therapies were considered exposed. The main outcome was non-response to hepatitis B vaccination. Bivariate analysis was conducted to detect differences between exposed and non-exposed patients. A multivariable log-binomial regression model was designed to analyze potential factors independently associated with non-responders. Results: A total of 289 patients were included. Immunosuppressive treatment was associated with non-response to hepatitis B vaccination (RR = 2.49, 95% CI: 1.26–4.96). Concretely, the use of cytotoxic therapies showed increased risk, although anti-CD20 and anti-JAK also showed a tendency to be associated with non-responders. Other variables associated with non-responders were older age (6–7% higher risk per year), smoking (RR = 3.08, 95% CI: 1.41–6.74) and certain vaccine regimens. These findings were similar for persistent non-responders despite an additional booster dose. Conclusions: Patients receiving immunosuppressive treatments, who are older in age or who are smokers have a higher risk of non-response to conventional hepatitis B vaccination. These data might serve to optimize hepatitis B vaccination in high-risk patients.},
publisher = {MDPI},
keywords = {Monoclonal antibodies},
keywords = {Biologics},
keywords = {Elderly},
keywords = {Smoking},
keywords = {Andalusia},
title = {Immunosuppressive Treatments and Risk Factors Associated with Non-Response to Hepatitis B Vaccination: A Cohort Study},
doi = {10.3390/vaccines13020184},
author = {Padilla-Matas, Raquel and Salguero-Cano, Victoria and Soler-Iborte, Eva and Baca-Hidalgo, Javier and Pérez-Dionisio, Marta and Gutiérrez-Linares, Soledad and Guerrero Fernández de Alba, Inmaculada and Valero Ubierna, María del Carmen and Fernández-Prada, María and Rivera Izquierdo, Mario},
}