@misc{10481/102812,
year = {2025},
month = {1},
url = {https://hdl.handle.net/10481/102812},
abstract = {Background

Although the genetic interplay with the environment has a major impact on obesity development, little is known on whether breastfeeding could modulate the genetic predisposition to obesity.
Objectives

To investigate whether breastfeeding attenuates the effect of an obesity genetic risk score (GRS) on adiposity in European adolescents.
Methods

Totally 751 adolescents from the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) cross-sectional study were included, divided according to breastfeeding status into never breastfed, 1–3 months and ≥4 months. Adjusting by socioeconomic status and lifestyle factors multiple linear regression models were used to assess (1) the main effect of breastfeeding duration and (2) its interaction effect with an obesity GRS, to predict different adiposity measures.
Results

A significant negative association between ≥4 months of breastfeeding and waist circumference (WC) z-score was observed [β (95% confidence interval), p-value] = [β = −0.189 (−0.37, −0.00), p = 0.044]. Also, significant interaction effects were observed for 1–3 and ≥4 months of breastfeeding and obesity GRS regarding body mass index (BMI) z-score [β = 0.155 (0.06, 0.24), p = 0.001] and [β = 0.108 (0.01, 0.18), p = 0.020, respectively] and fat mass index (FMI) z-score [β = 0.134 (0.04, 0.22), p = 0.003] and [β = 0.100 (0.01, 0.18), p = 0.026, respectively].
Conclusions

Breastfeeding modulates the association between the obesity GRS and body composition in adolescents.},
organization = {Health Institute Carlos III (ISCIII) PI20/00988},
organization = {European Community Sixth RTD Framework Programme  FOODCT-2005-007034},
organization = {European Union’s H2020 Marie Sklodowska-Curie  801586},
organization = {University of Zaragoza- Mecenazgo Santander},
publisher = {Wiley},
keywords = {Adolescents},
keywords = {Breastfeeding},
keywords = {Genetic risk score},
keywords = {HELENA Study},
keywords = {Interaction effect},
title = {Interaction between breastfeeding duration and an obesity genetic risk score to predict body fat composition in European adolescents: The HELENA study},
doi = {10.1111/ijpo.13205},
author = {Baxevanis, Georgios K. and Gutiérrez Sáinz, Ángel and HELENA study group},
}