@misc{10481/102488,
year = {2020},
month = {7},
url = {https://hdl.handle.net/10481/102488},
abstract = {Pressurized liquid extraction was performed to obtain a phytocomplex from Lippia citriodora leaves rich in
bioactive compounds. The extract was loaded in phospholipid vesicles to improve its protective effect against
oxidative stress in the intestine. The phytochemicals were identified and quantified by HPLC-ESI-TOF-MS. The
extract was incorporated in liposomes and penetration enhancer-containing vesicles (PEVs) modified with
glucidex, a dextrin, and a biopolymer obtained from Chimaera monstrosa. The PEVs were smaller than liposomes
(~150 vs 370 nm) and more stable, according to accelerated aging tests. The integrity of the vesicles in acidic or
neutral pH and high ionic strength or in milk whey was assessed. The cytocompatibility of the formulations and
their ability to protect Caco-2 cells against oxidative stress were confirmed in vitro and compared with two
commercial extracts of L. citriodora. The results confirmed the suitability of formulations to be used in functional
foods to protect the intestine from oxidative stress.},
organization = {AGL2015-67995-C3-2-R (Spanish
Ministry of Science and Innovation)},
organization = {P11-CTS-7625 (Andalusian
Regional Government Council of Innovation and Science)},
organization = {RTI2018-
096724-B-C22 (Ministry of science, Innovation and Universities)},
organization = {Leyva-Jimenez gratefully acknowledges the Spanish Ministry of
Economy and Competitiveness (MINECO) for the FPI grant BES-2016-
076618},
publisher = {Elsevier},
keywords = {Lippia citriodora},
keywords = {Green extracts},
keywords = {Phospholipid vesicles},
keywords = {Antioxidant activity},
keywords = {Caco-2 cells},
keywords = {Oral delivery},
title = {Development of advanced phospholipid vesicles loaded with Lippia citriodora pressurized liquid extract for the treatment of gastrointestinal disorders},
doi = {10.1016/j.foodchem.2020.127746},
author = {Leyva Jiménez, Francisco Javier and Manca, María Letizia and Manconi, María and Caddeo, Carla and Vázquez, José Antonio and Carbone, Claudia and Lozano Sánchez, Jesús and Arráez Román, David and Segura Carretero, Antonio},
}