@misc{10481/101835,
year = {2016},
month = {12},
url = {https://hdl.handle.net/10481/101835},
abstract = {Background: Clopidogrel has provided beneficial effects in acute coronary syndrome and percutaneous coronary intervention. Different polymorphisms have been associated with differences in clopidogrel response. The aim of this study was to check if CYP2C19/ABCB1-genotype-guided strategy reduces the rates of cardiovascular events and bleeding.

Methods: This experimental study included patients undergoing percutaneous coronary intervention with stent. The prospective genotype-guided strategy (intervention group) was compared against a retrospective non-tailored strategy (control group). Primary efficacy endpoint was the composite of cardiovascular death, acute coronary syndrome or stroke during 12months after intervention. Secondary endpoint was to compare the efficacy of the different antiplatelet therapies used in genotyping conditions.

Results: The study included 719 patients undergone stent, more than 86% with acute coronary syndrome. The primary endpoint occurred in 32 patients (10.1%) in the genotyping group and in 59 patients (14.1%) in the control group (HR 0.63, 95% CI (0.41-0.97), p =0.037). There was no difference in The Thrombolysis in Myocardial Infarction major and minor bleeding criteria between the two groups (4.1% vs. 4.7%, HR=0.80, 95% CI (0.39-1.63), p=0.55). In intervention group, there was no difference in the rate of events in patients treated with clopidogrel versus patients treated with other antiplatelet treatments (9.1% vs 11.5% p=0.44), or bleeding (3.7% vs 4.6%, p=0.69).

Conclusions: The genotype-guided strategy could reduce the rates of composite of cardiovascular events and bleeding during 12months after percutaneous coronary intervention compared to a non-genotype-guide strategy.},
organization = {Ministry of Health of the Government of Andalusia PI-057/2012},
publisher = {Elsevier},
keywords = {Clopidogrel},
keywords = {Genotype-guided antiplatelet therapy},
keywords = {CYP2C19},
keywords = {ABCB1},
title = {Results of genotype-guided antiplatelet therapy in patients who undergone percutaneous coronary intervention with stent},
doi = {10.1016/j.ijcard.2016.09.088},
author = {Sánchez Ramos, Jesús Gabriel and Dávila Fajardo, Cristina Lucía and Toledo Frías, Pablo and Díaz Villamarín, Xando and Martínez González, Luis Javier and Martínez Huertas, Susana and Burillo Gómez, Francisco and Caballero Borrego, Juan and Bautista Pavés, Alicia and Marín Guzmán, María Carmen and Ramírez Hernández, José Antonio and Correa Vilches, Concepción and Cabeza-Barrera, José},
}