@misc{10481/101808,
year = {2003},
url = {https://hdl.handle.net/10481/101808},
abstract = {Differential aspects of the host immune response generated by
Trypanosoma cruzi
infection were
examined in two different mouse strains, BALB/c (haplotype H2-K
d
) which does not overcome the
acute phase of the infection and C57BL/6 (haplotype H2-K
b
) which survives to the acute phase. After
infection an increase in CD3
+
T cells was observed in both mouse strains in the peritoneal cavity. However,
while the CD3
+
T cells from the BALB/c mice showed an increase in the IL-4 cytokine expression
level, the same type of cells from the C57BL/6 mice showed an increase in IFNg
expression. In addition,
only the macrophages from the C57BL/6 mice were activated secreting IL-12 and TNFa
and producing,
moreover, high levels of nitrites. It was observed that also after parasite infection the expression of macrophage
and dendritic cells CD40 and CD86 co-stimulation molecules from the spleen were diminished
in BALB/c but not in C57BL/6 mice. In correlation with this observation the macrophages from the
spleen of infected BALB/c mice secreted lower concentrations of nitrites than the C57BL/6 mouse cells.
Also, the spleen dendritic cells from infected BALB/c mice had a small potential to present alloantigens
in contrast to that observed in the infected C57BL/6 mouse cells.},
organization = {This work
was supported by Plan Nacional I +D–FEDER (DGESIC) (grant
1FD1997-0630-C02-01) Spain and Servicio Andaluz de Salud (grant 145/
2001) Spain},
publisher = {Clin Exp Immunol},
title = {Differential CD86 and CD40 co-stimulatory molecules and cytokine expression pattern induced by Trypanosoma cruzi in APCs from resistant or susceptible mice},
doi = {10.1046/j.1365-2249.2003.02022.x},
author = {Morell Hita, María},
}