@misc{10481/101622,
year = {2015},
month = {11},
url = {https://hdl.handle.net/10481/101622},
abstract = {Aims: The energy expenditure capacity of brown adipose tissue (BAT) makes it an attractive target as a therapy against obesity and type 2 diabetes. BAT activators namely catecholamines, natriuretic peptides and certain myokines, are secreted in response to exercise. ACTIBATE will determine the effect of exercise on BAT activity and mass measured by positron emission tomography/computed tomography (PET/CT, primary outcome) in young adults. ACTIBATE will also investigate the physiological consequences of activating BAT (secondary outcomes). 
Methods: ACTIBATE will recruit 150 sedentary, healthy, young adults (50% women) aged 18-25 years. Eligible participants will be randomly assigned to a non-exercise group (n=50) or one of two exercise groups (n=50 each). Participants in the exercise groups will perform aerobic and strength training 3-4 days/week at a heart rate equivalent to 60% of heart rate reserve (HRres), and at 50% of 1 repetition maximum (RM) for the moderate-intensity group, and at 80% of HRres and 70%RM for the vigorous-intensity group. Laboratory measures completed at baseline and 6 months include BAT activity and mass, resting energy expenditure, meal and cold-induced thermogenesis, body temperature regulation and shivering threshold, body composition and cardiovascular disease risk factors. We will also obtain biopsies from abdominal subcutaneous white adipose tissue and skeletal muscle to analyse the expression of genes encoding proteins involved in the thermogenic machinery.
Discussion: Findings from ACTIBATE will have significant implications for our understanding of exercise and its protective effects against the development of type 2 diabetes, obesity and related metabolic diseases.},
publisher = {Elsevier},
title = {Activating brown adipose tissue through exercise (ACTIBATE) in young adults: rationale, design and methodology},
doi = {10.1016/j.cct.2015.11.004},
author = {Sánchez Delgado, Guillermo and Martínez Téllez, Borja Manuel and Olza, Josune and Aguilera García, Concepción María and Labayen, Idoia and Ortega Porcel, Francisco Bartolomé and Chillón Garzón, Palma and Fernandez Reguera, Carlos and Alcántara Alcántara, Juan Manuel and Martinez Avila, Wendy D. and Muñoz Hernández, María Victoria and Acosta Manzano, Francisco Miguel and Prados Ruiz, Juan and Amaro Gahete, Francisco José and Hidalgo García, Laura and Rodríguez Pérez, Lorena and Abdel-Karim Ruiz, Yasmeen and Ramírez Navarro, Ángel Miguel and Muros de Fuentes, María Angustias and García Rivero, Encarnación Yolanda and Sánchez Sánchez, Rocío and Beas-Jiménez, Juan de Dios and de Teresa, Carlos and Navarrete, Socorro and Lozano, Rosa Maria and Brea Gomez, Esther and Rubio‑Lopez, Jose and Ruiz Ruiz, Maria and Cano-Nieto, Amalia and Llamas Elvira, José Manuel and Jiménez Ríos, José Antonio and Gil Hernández, Ángel and Ruiz Ruiz, Jonatan},
}