@misc{10481/101315,
year = {2016},
url = {https://hdl.handle.net/10481/101315},
abstract = {Aim: To develop biocompatible and bioresorbable negatively charged calcium phosphate nanoparticles (CaP-NPs) as an innovative therapeutic system for the delivery of bioactive molecules to the heart. Materials & methods: CaP-NPs were synthesized via a straightforward one-pot biomineralization-inspired protocol employing citrate as a stabilizing agent and regulator of crystal growth. CaP-NPs were administered to cardiac cells in vitro and effects of treatments were assessed. CaP-NPs were administered in vivo and delivery of microRNAs was evaluated. Results: CaP-NPs efficiently internalized into cardiomyocytes without promoting toxicity or interfering with any functional properties. CaP-NPs successfully encapsulated synthetic microRNAs, which were efficiently delivered into cardiac cells in vitro and in vivo. Conclusion: CaP-NPs are a safe and efficient drug-delivery system for potential therapeutic treatments of polarized cells such as cardiomyocytes.},
keywords = {Calcium phosphate},
keywords = {microRNA},
keywords = {Nanomedicine},
keywords = {Cardiomyocytes},
keywords = {Drug-delivery},
title = {Bioinspired negatively charged calcium phosphate nanocarriers for cardiac delivery of MicroRNAs},
doi = {10.2217/nnm.16.26},
author = {Di Mauro, Vittoria and Iafisco, Michele and Salvarini, Nicolo and Vacchiano, Marco and Carullo, Pierluigi and Ramírez-Rodríguez, Gloria Belén and Patricio, Tatiana and Tampieri, Anna and Miragoli, Michele and Catalucci, Daniele},
}