@misc{10481/101261,
year = {2016},
url = {https://hdl.handle.net/10481/101261},
abstract = {Over-expression of the early neural inducer, Noggin, in nestin positive subventricular zone (SVZ), neural stem
 cells (NSC) promotesproliferation and neuronal differentiation of neural progenitors and inhibits theexpression
 ofaCNS-enrichedmicroRNA-410(miR-410)(Morelletal.,2015).Whenexpressedinneurospheresderivedfrom
 the adultSVZ, miR-410inhibits neuronal andoligodendrocyte differentiation, and promotes astrocyte differenti
ation. miR-410 also reverses the increase in neuronal differentiation and decreased astroglial differentiation
 caused by Noggin over-expression. Conversely, inhibition of miR-410 activity promotes neuronal and decreases
 astroglial differentiation of NSC. Using computer prediction algorithms and luciferase reporter assays we identi
f
 ied multiple neurogenic genes including Elavl4 as downstream targets of miR-410 via the canonical miRNA-3′
 UTR interaction. Over-expression of Elavl4 transcripts without the endogenous 3′UTR rescued the decrease in
 neuronal differentiation caused by miR-410 overexpression. Interestingly, we also observedthat miR-410 affect
edneurite morphology;over-expressionof miR-410resultedintheformation ofshort,unbranchedneurites. We
 conclude that miR-410 expression provides a new link between BMP signaling and the crucial lineage choice of
 adult neural stem cells via its ability to bind and control the expression of neurogenic gene transcripts.},
organization = {The  work was supported by NIH grant NS-048187},
publisher = {Stem Cell Research},
title = {miR-410 controls adult SVZ neurogenesis by targeting neurogenic genes},
doi = {10.1016/j.scr.2016.07.003},
author = {Morell Hita, María},
}