@misc{10481/101212,
year = {2022},
month = {2},
url = {https://hdl.handle.net/10481/101212},
abstract = {The aim of this study was to develop and refine a heterologous mouse model of endometriosis-associated pain in which non-evoked responses, more relevant to the patient experience, were evaluated. Immunodeficient female mice (N = 24) were each implanted with four endometriotic human lesions (N = 12) or control tissue fat (N = 12) on the abdominal wall using tissue glue. Evoked pain responses were measured biweekly using von Frey filaments. Non-evoked responses were recorded weekly for 8 weeks using a home cage analysis (HCA). Endpoints were distance traveled, social proximity, time spent in the center vs. outer areas of the cage, drinking, and climbing. Significant differences between groups for von Frey response, climbing, and drinking were detected on days 14, 21, and 35 post implanting surgery, respectively, and sustained for the duration of the experiment. In conclusion, a heterologous mouse model of endometriosis-associated evoked a non-evoked pain was developed to improve the relevance of preclinical models to patient experience as a platform for drug testing.},
organization = {This project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement no. (777500). This Joint Undertaking receives support from the European Union’s Horizon 2020 research and innovation program and EFPIA. Further information is found under www.imi-paincare.eu (accessed on 16 February 2022) and www.imi.europa.eu (accessed on 16 February 2022). Additional funding was supported by the Spanish Ministry of Economy and Competitiveness through the Miguel Servet Program (CPII18/00037 (2018)) cofounded by FEDER (European Regional Development Fund) awarded to Raul Gómez as well as by Carlos III Institute of Health grants (PI17/02329 (2017) and PI20/01835 (2020)) awarded to Raul Gómez and predoctoral PFIS FI18/00322 (2018) awarded to Ana Santos.},
publisher = {Multidisciplinary Digital Publishing Institute},
keywords = {Endomet},
keywords = {Heterologous model},
keywords = {evoked and non-evoked response},
title = {Identification of Altered Evoked and Non-Evoked Responses in a Heterologous Mouse Model of Endometriosis-Associated Pain},
doi = {10.3390/biomedicines10020501},
author = {Tejada, MA and Santos-Llamas, A and Escriva, L and Tarin, JJ and Fernández-Ramirez, MJ and Nunez-Badinez, P and De Leo, B and Saunders, PTK and Vidal, V and Barthas, F and Vicent, K and Sweeney, PJ and Sillito, RR and Armstrong, JD and Nagel, J and Gomez, R},
}