@misc{10481/101086,
year = {2008},
month = {7},
url = {https://hdl.handle.net/10481/101086},
abstract = {This paper describes the activity against Anisakis simplex s.l. L3 larvae of six monoterpenic derivatives obtained from different essential oils, (α-pinene, β-pinene, ocimene, myrcene, geranyl acetate, and cineole). In in vitro assays, α-pinene, ocimene and cineole showed high activity at a concentration of 125 μg/mL (48 h) but only α-pinene and ocimene were active at 62.5 μg/mL. In in vivo assays, L3 larvae and study compounds were simultaneously administered per os to Wistar rats. The most active compound was α-pinene, finding lesions in only 20% of treated rats versus 98% of controls. Further in vivo studies are required to investigate whether addition of these compounds to food could have a prophylactic effect, reducing the pathogenicity of A. simplex s.l. L3 in humans, and to explore any possible synergy among compounds.},
organization = {This work was partly funded by the Research Groups grant from the Junta de Andalucía, Spain},
publisher = {Experimental Parasitology},
keywords = {Anisakis simplex s.l.},
keywords = {Larvicidal activity},
keywords = {Monoterpenic derivatives},
keywords = {α-Pinene},
keywords = {Ocimene},
keywords = {nutrition education},
title = {Anisakis simplex s.l.: Larvicidal activity of various monoterpenic derivatives of natural origin against L3 larvae in vitro and in vivo},
doi = {https://doi.org/10.1016/j.exppara.2008.07.014},
author = {Navarro, M.C. and Noguera, M.A. and Romero, M.C. and Montilla, M.P. and González de Selga, J.M. and Valero, A},
}