TY  - JOUR 
AU  - Henríquez-Hernández, Luis Alberto
AU  - Valenciano, Almudena
AU  - Foro-Arnalot, Palmira
AU  - Álvarez Cubero, María Jesús
AU  - Cózar Olmo, José Manuel
AU  - Suárez-Novo, José Francisco
AU  - Castells-Esteve, Manel
AU  - Fernández-Gonzalo, Pablo
AU  - De-Paula-Carranza, Belén
AU  - Ferrer, Montse
AU  - Guedea, Ferrán
AU  - Sancho-Pardo, Gemma
AU  - Craven-Bartle, Jordi
AU  - Ortiz-Gordillo, María José
AU  - Cabrera-Roldán, Patricia
AU  - Herrera-Ramos, Estefanía
AU  - Rodríguez-Gallego, Carlos
AU  - Rodríguez-Melcon, Juan Ignacio
AU  - Lara, Pedro C.
PY  - 2014
SN  - 1471-2350
UR  - http://hdl.handle.net/10481/35776
AB  - Background

Besides serum levels of PSA, there is a lack of prostate cancer specific biomarkers. It is need to develop new biological markers associated with the tumor behavior which would be valuable to better individualize treatment. The aim of...
AB  - Methods

A total of 494 prostate cancer patients from a Spanish multicenter study were genotyped for 10 SNPs in XRCC1, ERCC2, ERCC1, LIG4, ATM and TP53 genes. The SNP genotyping was made in a Biotrove OpenArray® NT Cycler. Clinical tumor stage,...
AB  - Results

SNPs rs11615 (ERCC1) and rs17503908 (ATM) appeared as risk factors for prostate cancer aggressiveness. Patients wild homozygous for these SNPs (AA and TT, respectively) were at higher risk for developing cT2b – cT4 (OR = 2.21 (confidence...
AB  - Conclusions

Genetic variants at DNA repair genes are associated with prostate cancer progression, and would be taken into account when assessing the malignancy of prostate cancer.
LA  - eng
PB  - Biomed Central
KW  - Single nucleotide polymorphism
KW  - ERCC1
KW  - ATM
KW  - Prostate cancer
KW  - OpenArray
KW  - DNA repair
KW  - Spanish cohort
TI  - Single nucleotide polymorphisms in DNA repair genes as risk factors associated to prostate cancer progression
DO  - 10.1186/s12881-014-0143-0
ER  -