Physiological Mechanisms Inherent to Diabetes Involved in the Development of Dementia: Alzheimer’s Disease Mohamed Mohamed, Himan García Morales, Victoria Sánchez Lara, Encarnación María González Acedo, Anabel Pardo Moreno, Teresa Tovar Gálvez, María Isabel Melguizo Rodríguez, Lucía Raquel Ramos Rodríguez, Juan José Alzheimer’s disease Dementia Vascular dementia Type 2 diabetes mellitus (T2D) is a metabolic disease reaching pandemic levels worldwide. In parallel, Alzheimer’s disease (AD) and vascular dementia (VaD) are the two leading causes of dementia in an increasingly long-living Western society. Numerous epidemiological studies support the role of T2D as a risk factor for the development of dementia. However, few basic science studies have focused on the possible mechanisms involved in this relationship. On the other hand, this review of the literature also aims to explore the relationship between T2D, AD and VaD. The data found show that there are several alterations in the central nervous system that may be promoting the development of T2D. In addition, there are some mechanisms by which T2D may contribute to the development of neurodegenerative diseases such as AD or VaD. 2024-04-26T10:37:32Z 2024-04-26T10:37:32Z 2023-10-10 info:eu-repo/semantics/article Mohamed-Mohamed, H.; García-Morales, V.; Sánchez Lara, E.M.; González-Acedo, A.; Pardo-Moreno, T.; Tovar-Gálvez, M.I.; Melguizo-Rodríguez, L.; Ramos-Rodríguez, J.J. Physiological Mechanisms Inherent to Diabetes Involved in the Development of Dementia: Alzheimer’s Disease. Neurol. Int. 2023, 15, 1253–1272. https://doi.org/10.3390/neurolint15040079 https://hdl.handle.net/10481/91191 10.3390/neurolint15040079 eng http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Atribución 4.0 Internacional MDPI