A Web-Based Exercise System (e-CuidateChemo) to Counter the Side Effects of Chemotherapy in Patients With Breast Cancer: Randomized Controlled Trial Ariza García, Carmen Angélica Lozano Lozano, Mario Galiano Castillo, Noelia Postigo Martín, Elisa Paula Arroyo Morales, Manuel Canterero Villanueva, Irene Breast cancer Physical fitness Randomized control trial Therapeutic exercise Chemotherapy Background: Breast cancer patients have to face a high-risk state during chemotherapy, which involves deterioration of their health including extensive physical deterioration. Face-to-face physical exercise programs have presented low adherence rates during medical treatment, and telehealth systems could improve these adherence rates. Objective: This study aimed to evaluate the effectiveness of a Web-based exercise program (e-CuidateChemo) to mitigate the side effects of chemotherapy on the physical being, anthropometric aspects, and body composition. Results: Functional capacity improved significantly in the e-CuidateChemo group compared to the control group (6-minute walk test: 62.07 [SD 130.09] m versus –26.34 [SD 82.21] m; 6-minute walk test % distance predicted: 10.81% [SD 22.69%] m versus –4.60% [SD 14.58%]; between-group effect: P=.015 for both). The intervention group also showed significantly improved secondary outcomes such as between-group effects for abdominal (24.93 [SD 26.83] s vs –18.59 [SD 38.69] s), back (12.45 [SD 10.20] kg vs 1.39 [10.72] kg), and lower body (–2.82 [SD 3.75] s vs 1.26 [SD 2.84] s) strength; all P<.001 compared to the control group. Conclusions: This paper showed that a Web-based exercise program was effective in reversing the detriment in functional capacity and strength due to chemotherapy. 2020-04-28T11:56:57Z 2020-04-28T11:56:57Z 2019 info:eu-repo/semantics/article Ariza-Garcia, A., Lozano-Lozano, M., Galiano-Castillo, N., Postigo-Martin, P., Arroyo-Morales, M., & Cantarero-Villanueva, I. (2019). A Web-Based Exercise System (e-CuidateChemo) to Counter the Side Effects of Chemotherapy in Patients With Breast Cancer: Randomized Controlled Trial. Journal of medical Internet research, 21(7), e14418. http://hdl.handle.net/10481/61660 10.2196/14418 eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España JMIR Publications, Inc.