Potential Relevance of Melatonin Against Some Infectious Agents: A Review and Assessment of Recent Research
Metadatos
Mostrar el registro completo del ítemAutor
Elmahallawy, Ehab Kotb; Ortega Luque, Javier; Aloweidi, Abdelkarim Saleh; Gutiérrez Fernández, José; Sampedro Martínez, Antonio; Rodriguez-Granger, Javier; Kaki, Abdullah; Agil Abdalla, Mhmad AhmadEditorial
Bentham Science Publishers
Materia
Bacterial and viral infection Immune system modulation Ion fluxes Melatonin Parasite Therapeutic effects
Fecha
2015Referencia bibliográfica
Elmahallawy EK, Luque JO, Aloweidi AS, Gutiérrez-Fernández J, Sampedro-Martínez A, Rodriguez-Granger J, Kaki A, Agil A. Potential Relevance of Melatonin Against Some Infectious Agents: A Review and Assessment of Recent Research. Curr Med Chem. 2015;22(33):3848-61. DOI: 10.2174/0929867322666150827093730
Patrocinador
Erasmus Mundus scholarshipResumen
Melatonin, a tryptophan-derived neurohormone found in animals, plants, and microbes, participates in various biological and physiological functions. Among other properties, numerous in vitro or in vivo studies have reported its therapeutic potential against many parasites, bacteria and viruses. In this concern, melatonin was found to be effective against many parasites such as Plasmodium, Toxoplasma gondii, and Trypansoma cruzi, via various mechanisms such as modulation of calcium level and/or host immune system. Likewise, a recent investigation has reported in vitro activity of melatonin against Leishmania infantum promastigotes which is the causative agent of fascinating visceral Leishmaniasis. This review was initially undertaken to summarize some facts about certain physiological and therapeutic effects of melatonin. It also reviews the effects and action mechanisms of melatonin in bacterial and viral infection besides biology of different parasites which may provide a promising strategy for control of many diseases of public health importance.