Systematic Review Nanomedicine and Hyperthermia for the Treatment of Gastrointestinal Cancer: A Systematic Review
Metadatos
Mostrar el registro completo del ítemAutor
Gago Bejarano, Lidia; Quiñonero Muñoz, Francisco José; Perazzoli, Gloria; Melguizo Alonso, Consolación; Prados Salazar, José Carlos; Ortiz Quesada, Raúl; Cabeza Montilla, LauraEditorial
MDPI
Materia
Gastrointestinal cancer Magnetic nanoparticles Hyperthermia Cytotoxic drugs
Fecha
2023-07-15Referencia bibliográfica
Gago, L.; Quiñonero, F.; Perazzoli, G.; Melguizo, C.; Prados, J.; Ortiz, R.; Cabeza, L. Nanomedicine and Hyperthermia for the Treatment of Gastrointestinal Cancer: A Systematic Review. Pharmaceutics 2023, 15, 1958. [https://doi.org/10.3390/pharmaceutics15071958]
Patrocinador
PI19/01478 and PMPTA22/00136 (Instituto de Salud Carlos III) (FEDER); Project P20_00540, A-CTS-666-UGR20; B-CTS-122-UGR20 and PYC20 RE 035 (Proyectos I + D + i Junta de Andalucía 2020) (FEDER); FP-PRE grant (2021) from the Junta de Andalucia (Spain)Resumen
The incidence of gastrointestinal cancers has increased in recent years. Current treatments
present numerous challenges, including drug resistance, non-specificity, and severe side effects,
needing the exploration of new therapeutic strategies. One promising avenue is the use of magnetic
nanoparticles, which have gained considerable interest due to their ability to generate heat in
tumor regions upon the application of an external alternating magnetic field, a process known as
hyperthermia. This review conducted a systematic search of in vitro and in vivo studies published in
the last decade that employ hyperthermia therapy mediated by magnetic nanoparticles for treating
gastrointestinal cancers. After applying various inclusion and exclusion criteria (studies in the last
10 years where hyperthermia using alternative magnetic field is applied), a total of 40 articles were
analyzed. The results revealed that iron oxide is the preferred material for magnetism generation
in the nanoparticles, and colorectal cancer is the most studied gastrointestinal cancer. Interestingly,
novel therapies employing nanoparticles loaded with chemotherapeutic drugs in combination with
magnetic hyperthermia demonstrated an excellent antitumor effect. In conclusion, hyperthermia
treatments mediated by magnetic nanoparticles appear to be an effective approach for the treatment
of gastrointestinal cancers, offering advantages over traditional therapies