Swine as the Animal Model for Testing New Formulations of Anti-Inflammatory Drugs: Carprofen Pharmacokinetics and Bioavailability of the Intramuscular Route
Metadatos
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MDPI
Materia
Population pharmacokinetics Tissue distribution Swine animal model Mass spectrometry Bioanalysis Carprofen Anti-inflammatory drugs
Fecha
2022-05-12Referencia bibliográfica
Gómez-Segura, L... [et al.]. Swine as the Animal Model for Testing New Formulations of Anti-Inflammatory Drugs: Carprofen Pharmacokinetics and Bioavailability of the Intramuscular Route. Pharmaceutics 2022, 14, 1045. [https://doi.org/10.3390/pharmaceutics14051045]
Resumen
Carprofen (CP) is a non-steroidal anti-inflammatory drug (NSAID) frequently used to
treat respiratory diseases in numerous small animals, but also in large species. CP is a formidable
candidate for further therapeutic research of human inflammatory diseases using the pig as an animal
model. However, CP administration in swine is very uncommon and respective pharmacokinetics/
bioavailability studies are scarce. A simultaneous population pharmacokinetic analysis after CP
intravenous and intramuscular administrations in pigs has shown high extent and rate of absorption
and a similar distribution profile with respect to man and other mammals. However, clearance and
half-life values found in swine suggest a slower elimination process than that observed in man and
some other animal species. Although not reported in other species, liver and kidney concentrations
achieved at 48 h post-intramuscular administration in pigs were ten times lower than those found in
plasma. Simulations pointed to 4 mg/kg every 24 h as the best dosage regimen to achieve similar
therapeutic levels to those observed in other animal species. All these findings support the use of pig
as an animal model to study the anti-inflammatory effects of CP in humans.