Extracellular vesicles in parasitic diseases
Metadatos
Mostrar el registro completo del ítemEditorial
Taylor y Francis LTD
Materia
Extracellular vesicles Microvesicles Exosomes Parasites Protozoa Helminths
Fecha
2014-12-22Referencia bibliográfica
Antonio Marcilla, Lorena Martin-Jaular, Maria Trelis, Armando de Menezes- Neto, Antonio Osuna, Dolores Bernal, Carmen Fernandez-Becerra, Igor C. Almeida & Hernando A. del Portillo (2014) Extracellular vesicles in parasitic diseases, Journal of Extracellular Vesicles, 3:1, 25040, [DOI: 10.3402/jev.v3.25040]
Patrocinador
National Council for Scientific and Technological Development (CNPq); United States Department of Health & Human Services National Institutes of Health (NIH) - USA R01AI070655-A5 R01AI070655-A5S1 2G12MD007592; European Union (EU); Ministerio Español de Economía y CompetitividadResumen
Parasitic diseases affect billions of people and are considered a major public health issue. Close to 400 species
are estimated to parasitize humans, of which around 90 are responsible for great clinical burden and mortality
rates. Unfortunately, they are largely neglected as they are mainly endemic to poor regions. Of relevance to
this review, there is accumulating evidence of the release of extracellular vesicles (EVs) in parasitic diseases,
acting both in parasite parasite inter-communication as well as in parasite host interactions. EVs participate
in the dissemination of the pathogen and play a role in the regulation of the host immune systems. Production
of EVs from parasites or parasitized cells has been described for a number of parasitic infections. In this
review, we provide the most relevant findings of the involvement of EVs in intercellular communication,
modulation of immune responses, involvement in pathology, and their potential as new diagnostic tools and
therapeutic agents in some of the major human parasitic pathogens.