Beneficial Effects of Different Flavonoids on Vascular and Renal Function in L-NAME Hypertensive Rats
Metadatos
Mostrar el registro completo del ítemAutor
Paredes, M. Dolores; Romecín, Paola; Atucha, Noemí M.; O'Valle Ravassa, Francisco Javier; Castillo, Julián; Ortiz, María Clara; García-Estañ, JoaquínEditorial
MDPI
Materia
Flavonoids Nitric oxide Neart Kidney Sodium balance Phenylephrine Acetylcholine
Fecha
2018-04-13Referencia bibliográfica
Paredes, M. D. [et al.]. Beneficial Effects of Different Flavonoids on Vascular and Renal Function in L-NAME Hypertensive Rats. Nutrients 2018, 10, 484. [http://hdl.handle.net/10481/54900]
Patrocinador
This report was supported by a grant from the National Spanish R&D Program CENIT of the Spanish Ministry of Science and Technology denominated “Industrial research diets and food with specific features for the elderly”, CEN-20091006; Acronym: SENIFOOD.We have not received funds for covering the costs to publish in open access. We acknowledge the assistance of Justin Davis with the English language.Resumen
Background: we have evaluated the antihypertensive effect of several flavonoid extracts
in a rat model of arterial hypertension caused by chronic administration (6 weeks) of the nitric
oxide synthesis inhibitor, L-NAME. Methods: Sprague Dawley rats received L-NAME alone or
L-NAME plus flavonoid-rich vegetal extracts (Lemon, Grapefruit + Bitter Orange, and Cocoa) or
purified flavonoids (Apigenin and Diosmin) for 6 weeks. Results: L-NAME treatment resulted in a
marked elevation of blood pressure, and treatment with Apigenin, Lemon Extract, and Grapefruit +
Bitter Orange extracts significantly reduced the elevated blood pressure of these animals. Apigenin
and some of these flavonoids also ameliorated nitric oxide-dependent and -independent aortic
vasodilation and elevated nitrite urinary excretion. End-organ abnormalities such as cardiac infarcts,
hyaline arteriopathy and fibrinoid necrosis in coronary arteries and aorta were improved by these
treatments, reducing the end-organ vascular damage. Conclusions: the flavonoids included in this
study, specially apigenin, may be used as functional food ingredients with potential therapeutic
benefit in arterial hypertension.