@misc{10481/87326,
year = {2018},
url = {https://hdl.handle.net/10481/87326},
abstract = {The combination of controlled living polymerization in association with rapid and highly efficient macromolecule conjugation strategies provides a powerful tool for the synthesis of novel polymeric materials. Here functional block copolymers were rapidly and quantitatively conjugated using an efficient reaction between polymers containing a phenolic group and the 4-phenyl-3H-1,2,4-triazole-3,5(4H)-dione (PTAD) moiety and used to generate nanoparticles that encapsulated drugs. pH responsive amphiphilic block copolymers, which self-assemble into nanoparticles, were fabricated using our novel polymer conjugation strategy with the resulting system designed to promote drug release within the acidic milieu of the cancer microenvironment. The conjugation strategy also enabled the direct tagging of the nanoparticles with a range of fluorophores, targeting assets, or both with cargo release demonstrated in cancer cells.},
organization = {This work was funded by the European Research Council
(Advanced Grant ADREEM ERC-2013-340469). W.L. ac knowledges support from the Chinese Scholarship Council. We
thank the Wellcome Trust for the Multi User Equipment Grant
WT104915MA.},
publisher = {ACS},
title = {Rapid Polymer Conjugation Strategies for the Generation of pH-Responsive, Cancer Targeting, Polymeric Nanoparticles},
doi = {10.1021/acs.biomac.8b00309},
author = {Li, Weishuo and Geng, Jin and Titmarsh, Helen and Megía Fernández, Alicia and Dhaliwal, Kev and Frame, Margaret and Bradley, Mark},
}