@misc{10481/86511,
year = {2014},
month = {8},
url = {https://hdl.handle.net/10481/86511},
abstract = {Decidualization triggers the secretion of soluble factors that induce apoptosis in DSC. The differentiation and apoptosis of DSC during decidualization of the receptive decidua are crucial processes for the controlled invasion of trophoblasts in normal pregnancy. Most DSC regress in a time-dependent manner, and their removal is important to provide space for the embryo to grow. However, the mechanism that controls DSC death is poorly understood. DSCs were resistant to a variety of apoptosis-inducing substances. Nevertheless, DSC underwent apoptosis during decidualization in culture, withcAMPbeing essential for both apoptosis and differentiation. In addition, culture supernatants from decidualizedDSCinduced apoptosis in undifferentiatedDSC, although paradoxically these supernatants decreased the spontaneous apoptosis of decidual lymphocytes. Exogenously added PRLdid not induce apoptosis inDSCand an antibody that neutralized the PRLreceptor did not decrease the apoptosis induced by supernatants.},
organization = {This work was supported by the Consejería de Economía, Innovación y Ciencia, Junta de Andalucía (Grant CTS-6183, Proyectos de Investigación de Excelencia 2010 to C.R.-R.) and the Instituto de Salud Carlos III, Ministerio de Economía y Competitividad, Spain (Grants PS09/00339 and PI12/01085 to E.G.O.). E.L.-D. was supported by fellowships from the Ministerio de Educación y Ciencia, Spain and the University of Granada.},
publisher = {OXFORD JOURNALS},
keywords = {DSC},
keywords = {Apoptosis},
keywords = {Decidualization},
title = {Human decidual stromal cells secrete soluble pro-apoptotic factors during decidualization in a cAMP-dependent manner},
doi = {10.1093/humrep/deu202},
author = {Leno-Durán, Esther and Ruiz Magaña, María José and Muñoz Fernández, Raquel and García Olivares, Enrique and Ruiz Ruiz, Carmen},
}