@misc{10481/80978,
year = {2023},
month = {2},
url = {https://hdl.handle.net/10481/80978},
abstract = {Drug–drug salts are a kind of pharmaceutical multicomponent solid in which the two
co-existing components are active pharmaceutical ingredients (APIs) in their ionized forms. This
novel approach has attracted great interest in the pharmaceutical industry since it not only allows
concomitant formulations but also has proved potential to improve the pharmacokinetics of the
involved APIs. This is especially interesting for those APIs that have relevant dose-dependent secondary
effects, such as non-steroidal anti-inflammatory drugs (NSAIDs). In this work, six multidrug
salts involving six different NSAIDs and the antibiotic ciprofloxacin are reported. The novel solids
were synthesized using mechanochemical methods and comprehensively characterized in the solid
state. Moreover, solubility and stability studies, as well as bacterial inhibition assays, were performed.
Our results suggest that our drug–drug formulations enhanced the solubility of NSAIDs without
affecting the antibiotic efficacy.},
organization = {FPI grant	B-FQM-478-UGR20
AGL-2015-68806-R},
organization = {Spanish Agencia Estatal de Investigacion of the Ministerio de Ciencia e Innovacion},
publisher = {MDPI},
keywords = {NSAIDs},
keywords = {Ciprofloxacin},
keywords = {Molecular salts},
keywords = {Mechanochemistry},
keywords = {Crystal engineering},
title = {Enhanced NSAIDs Solubility in Drug–Drug Formulations with Ciprofloxacin},
doi = {10.3390/ijms24043305},
author = {Acebedo Martínez, Francisco Javier and Domínguez Martín, Alicia and Alarcón Payer, Carolina and Sevillano Páez, Alejandro and Verdugo Escamilla, Cristóbal and González Pérez, Josefa María and Martínez-Checa Barrero, Fernando José and Choquesillo Lazarte, Duane},
}