@misc{10481/80468,
year = {2021},
month = {5},
url = {https://hdl.handle.net/10481/80468},
abstract = {A set of 12 maslinic acid−coumarin conjugates was
synthesized, with 9 being maslinic acid−diamine−coumarin
conjugates at the C-28 carboxylic acid group of triterpene acid
and the other three being maslinic acid−coumarin conjugates at C-
2/C-3 and/or C-28 of the triterpene skeleton. The cytotoxic effects
of these 12 triterpene conjugates were evaluated in three cancer
cell lines (B16-F10, HT29, and Hep G2) and compared,
respectively, with three nontumor cell lines from the same or
similar tissue (HPF, IEC-18, and WRL68). The most potent
cytotoxic results were achieved by a conjugate with two molecules
of coumarin-3-carboxylic acid coupled through the C-2 and C-3
hydroxy groups of maslinic acid. This conjugate showed
submicromolar IC50 values in two of the three cancer cell lines tested (0.6, 1.1, and 0.9 μM), being between 110- and 30-fold
more effective than its corresponding precursor. Furthermore, this conjugate (10) showed percentages of cell viability for the three
nontumor lines of 90%. Four maslinic acid−coumarin conjugates displayed apoptotic effects in the treated cells, with total apoptosis
rates of between 40 and 85%, relative to the control. Almost all the compounds assayed caused cell-cycle arrest in all cancer cell lines,
increasing the number of these cells in the G0/G1 phase.},
organization = {Junta de Andalucia	B1-FQM-217-UGR18
B1-BIO-281-UGR18},
publisher = {American Chemical Society},
title = {Synthesis and Biological Activity of Triterpene-Coumarin Conjugates},
doi = {10.1021/acs.jnatprod.1c00128},
author = {Vega Granados, Dulce Karina and Medina O'Donnell, Marta and Rivas Sánchez, Francisco De Asís and Reyes Zurita, Fernando Jesús and Martínez Rodríguez, Antonio and Álvarez  Cienfuegos Rodríguez, Luis and Lupiáñez Cara, José Antonio and Parra Sánchez, Andrés},
}