@misc{10481/80458,
year = {2021},
month = {7},
url = {https://hdl.handle.net/10481/80458},
abstract = {Objective
Impacted third molar extraction is associated with acute moderate-to-severe
pain for up to 48 hours post-surgery. This trial was designed to compare the
analgesic effectiveness, swelling, and adverse events after impacted third molar
surgery following multimodal therapy with 75 mg tramadol hydrochloride plus
25 mg dexketoprofen or monotherapy with 400 mg ibuprofen.
Methods
Seventy-two patients were randomly assigned to receiving ibuprofen (n = 36) or
tramadol-dexketoprofen (n = 36). Postoperative pain intensity and swelling were
measured using a visual analog scale (VAS); pain relief experienced was reported
using a 4-point verbal rating scale; the rescue medication requirement, adverse
effects, and global impression of the medication were recorded.
Results
No statistically significant between-group difference in pain intensity was observed
at any time point; however, pain relief was significantly higher in the
tramadol-dexketoprofen treated-group at 6 and 36 hours. Self-reported verbal
rating scale assessments showed significantly lower swelling in the tramadoldexketoprofen
group at 24 hours post-surgery but not at 48 or 72 hours, and VAS-
swelling scores showed no significant between-group difference. The frequency
of postoperative nausea and dizziness was significantly higher in the tramadoldexketoprofen
group.
Conclusions
Multimodal therapy proved more effective to manage moderate-severe pain after
impacted third molar surgery in comparison to monotherapy. However, the
improvement in relief must be balanced against the increased risk of adverse
effects when considering this multimodal approach.},
publisher = {Elsevier},
keywords = {Pain management},
keywords = {Analgesia},
keywords = {Acute pain},
keywords = {Multimodal treatment},
keywords = {Oral surgery},
title = {Analgesic efficacy of tramadol/dexketoprofen vs Ibuprofen after impacted lower third molar extraction: a randomized controlled clinical trial},
doi = {10.1016/j.jebdp.2021.101618},
author = {Vallecillo, Cristina and Vallecillo Rivas, Marta and Gálvez Mateos, Rafael and Vallecillo Capilla, Manuel Francisco and Olmedo Gaya, María Victoria},
}