@misc{10481/80379,
year = {2023},
month = {1},
url = {https://hdl.handle.net/10481/80379},
abstract = {Aim: Patients with type 2 diabetes (T2DM) have more risk of bone fractures.
However, areal bone mineral density (aBMD) by conventional dual-energy xray
absorptiometry (DXA) is not useful for identifying this risk. This study aims to
evaluate 3D-DXA parameters determining the cortical and trabecular
compartments in patients with T2DM compared to non-diabetic subjects
and to identify their determinants.
Materials and methods: Case-control study in 111 T2DM patients (65.4 ± 7.6
years old) and 134 non-diabetic controls (64.7 ± 8.6-year-old). DXA, 3D-DXA
modelling via 3D-Shaper software and trabecular bone score (TBS) were used
to obtain aBMD, cortical and trabecular parameters, and lumbar spine
microarchitecture, respectively. In addition, biochemical markers as 25-
hydroxyvitamin d, type I procollagen N-terminal propeptide (P1NP), Cterminal
telopeptide of type I collagen (CTX), and glycated haemoglobin
(HbA1c) were analysed.
Results: Mean-adjusted values showed higher aBMD (5.4%-7.7%, ES: 0.33-
0.53) and 3D-DXA parameters (4.1%-10.3%, ES: 0.42-0.68) in the T2DM group
compared with the control group. However, TBS was lower in the T2DM group
compared to the control group (-14.7%, ES: 1.18). In addition, sex (b = 0.272 to 0.316) and body mass index (BMI) (b = 0.236 to 0.455) were the most consistent
and positive predictors of aBMD (p ≤ 0.01). BMI and P1NP were negative
predictors of TBS (b = -0.530 and -0.254, respectively, p ≤ 0.01), while CTX was
a positive one (b = 0.226, p=0.02). Finally, BMI was consistently the strongest
positive predictor of 3D-DXA parameters (b = 0.240 to 0.442, p<0.05).
Conclusion: Patients with T2DM present higher bone mass measured both by
conventional DXA and 3D-DXA, suggesting that 3D-DXA technology is not
capable of identifying alterations in bone structure in this population.
Moreover, BMI was the most consistent determinant in all bone outcomes.},
organization = {Instituto de Salud Carlos III
grants (PI18–00803, PI21–01069, and PI18–01235)},
organization = {European Regional Development Fund (FEDER) Junta de Andalucı́a grant (PI-0268–2019)},
organization = {Programa Operativo Fondo Social Europeo
(FSE) de Andalucı́a (2014–2020) DOC_01618},
organization = {Instituto de Salud Carlos III
(CD20/00022)},
publisher = {Frontiers},
keywords = {Type 2 diabetes mellitus},
keywords = {3D-DXA},
keywords = {Bone modelling},
keywords = {Bone remodeling},
keywords = {Bone QCT/microCT},
title = {Do patients with type 2 diabetes have impaired hip bone microstructure? A study using 3D modeling of hip dual-energy X-ray absorptiometry},
doi = {10.3389/fendo.2022.1069224},
author = {Ubago Guisado, Esther and Moratalla Aranda, Enrique and González Salvatierra, Sheila and Gil Cosano, José Juan and García Fontana, Beatriz and García Fontana, Cristina and Gracia Marco, Luis Andrés and Muñoz Torres, Manuel Eduardo},
}