@misc{10481/49189,
year = {2017},
month = {6},
url = {http://hdl.handle.net/10481/49189},
abstract = {The role of dietary fat unsaturation and the supplementation of coenzyme Q have been evaluated in relation to bone health. Male Wistar rats were maintained for 6 or 24 months on two diets varying in the fat source, namely virgin olive oil, rich in monounsaturated fatty acids, or sunflower oil, rich in n-6 polyunsaturated fatty acids. Both dietary fats were supplemented or not with coenzyme Q10 (CoQ10). Bone mineral density (BMD) was evaluated in the femur. Serum levels of osteocalcin, osteopontin, receptor activator of nuclear factor κB ligand (RANKL), osteoprotegerin (OPG), adrenocorticotropin (ACTH) and parathyroid hormone (PTH), as well as urinary F2-isoprostanes were measured. Aged animals fed on virgin olive oil showed higher BMD than those fed on sunflower oil. In addition, CoQ10 prevented the age-related decline in BMD in animals fed on sunflower oil. Urinary F2-isoprostanes analysis showed that sunflower oil led to the highest oxidative status in old animals, which was avoided by supplementation with CoQ10. In conclusion, lifelong feeding on virgin olive oil or the supplementation of sunflower oil on CoQ10 prevented, at least in part mediated by a low oxidative stress status, the age-related decrease in BMD found in sunflower oil fed animals.},
organization = {This work was supported by the Spanish Ministry of Education and Science (AGL2008-01057) and the Autonomous Government of Andalusia (AGR832).},
publisher = {MDPI},
keywords = {Bone mineral density},
keywords = {F2-isoprostanes},
keywords = {Oxidative stress},
keywords = {MUFA},
keywords = {Polyunsaturated fatty acids (PUFA)},
title = {Loss of Bone Mineral Density Associated with Age in Male Rats Fed on Sunflower Oil Is Avoided by Virgin Olive Oil Intake or Coenzyme Q Supplementation},
doi = {10.3390/ijms18071397},
author = {Varela López, Alfonso and Ochoa Herrera, Julio José and Llamas Elvira, José Manuel and López Frías, Magdalena and Planells Del Pozo, Elena María and Speranza, Lorenza and Battino, Maurizio and Quiles Morales, José Luis},
}