@misc{10481/27390,
year = {2010},
url = {http://hdl.handle.net/10481/27390},
abstract = {The release and permeation studies were carried out for developing transdermal therapeutic systems with chlorpheniramine maleate (CPM). The patches were prepared with eudragit RS-100 and RL-100 with/without polyvinyl pyrrolidone (PVP) and dibutyl phthalate (DBP) in different compositions. Thickness, tensile strength, drug content, moisture content and water absorption studies of the patches were measured. In vitro release/permeation of CPM was studied in modified Keshary-Chien diffusion cell. Chemical enhancers like l-menthol, oleic acid and phospholipon80 were added to compare the release pattern of the drug. The percent release of the drug from matrix patch increased with increase of PVP & DBP but the tensile strength decreased with the increase of DBP & PVP. Experimental release/permeation data of different formulations of the matrix systems are reported. Also the drug-polymer interaction was investigated by ATR-FTIR studies. The discussion was correlated the efficient matrix dispersion patch from suitable eudragit polymers for transdermal antihistamine applications in film device industry.},
publisher = {Universidad de Granada, Facultad de Farmacia},
keywords = {Matrix patch},
keywords = {Chlorpheniramine malaeate},
keywords = {Chemical enhancers},
keywords = {Dibutyl phthalate},
keywords = {Eudragit polymer},
keywords = {Polyvinyl pyrrolidone},
title = {Design and in vitro evaluation of chlorpheniramine maleate from different eudragit based matrix patches: Effect of platicizer and chemical enhancers.},
author = {Rajan, R. and Sheba Rani, N.D. and Kajal, G. and Sanjoy Kumar, D. and Jasmina, K. and Arunabha, N.},
}