TY  - JOUR 
AU  - Manzano, Manuel
AU  - Girón González, María Dolores
AU  - Vílchez Rienda, José Dámaso
AU  - Sevillano Tripero, Natalia
AU  - El-Azem de Haro, Nuri
AU  - Rueda Cabrera, Ricardo
AU  - Salto González, Rafael
AU  - López-Pedrosa, José M.
PY  - 2016
SN  - 1743-7075
UR  - http://hdl.handle.net/10481/44824
AB  - Background:
Apple polyphenols could represent a novel nutritional approach in the management and control of blood glucose, especially in type 2 diabetics. The aim of this study was to test the therapeutic potential of an apple polyphenol extract...
AB  - Methods:

Acute effect of APE on the postprandial hyperglycemic response was assayed in 15 week old obese Zucker rats (OZR), by using a meal tolerance test (MTT). The ability of APE to improve whole peripheral insulin sensitivity was also assayed in...
AB  - Results:

In vivo study showed that nutritional intervention with APE induced an increase of insulin sensitivity with an increase of glucose infusion rate (GIR) of 45 %. Additionally, in vitro results showed a synergistic effect between APE and...
AB  - Conclusions:

As a whole, this study describes the mechanisms involved in the insulin sensitizing effect of APE, which could be considered a promising ingredient for inclusion in nutritional products focused on the management of chronic diseases...
LA  - eng
PB  - Biomed Central
KW  - Apple polyphenol extract
KW  - Insulin sensitivity
KW  - Blood glucose uptake
KW  - Skeletal muscle
KW  - Diabetes
TI  - Apple polyphenol extract improves insulin sensitivity in vitro and in vivo in animal models of insulin resistance
DO  - 10.1186/s12986-016-0088-8
ER  -