TY  - JOUR 
AU  - Li, Zhiguang
AU  - Qin, Taichun
AU  - Wang, Kejian
AU  - Hackenberg , Michael
AU  - Yan, Jian
AU  - Gao, Yuan
AU  - Yu, Li-Rong
AU  - Si, Zhengian Su
AU  - Chen, Tao
PY  - 2015
SN  - 1471-2164
UR  - http://hdl.handle.net/10481/36753
AB  - Background:

Aristolochic Acid (AA), a natural component of Aristolochia plants that is found in a variety of herbal remedies and health supplements, is classified as a Group 1 carcinogen by the International Agency for Research on Cancer. Given...
AB  - Results:

We treated rats with 10 mg/kg AA and vehicle control for 12 weeks and eight kidney samples (4 for the treatment and 4 for the control) were used for examining miRNA and mRNA expression by deep sequencing, and protein expression by...
AB  - Conclusions:

Our findings suggest that dysregulated miRNA expression plays an important role in AA-induced carcinogenesis in rat kidney, and that the integrated approach of multiple profiling provides a new insight into a post-transcriptional...
LA  - eng
PB  - Biomed Central
KW  - Aristolochic acid
KW  - Carcinogenesis
KW  - Kidney tumor
KW  - microRNA
KW  - Proteomics
KW  - Deep-Sequencing
KW  - RNA array
KW  - Target prediction
KW  - Rat
TI  - Integrated microRNA, mRNA, and protein expression profiling reveals microRNA regulatory networks in rat kidney treated with a carcinogenic dose of aristolochic acid
DO  - 10.1186/s12864-015-1516-2
ER  -