TY - JOUR AU - Sebastiani, Paola AU - Zhao, Zhenming AU - Abad Grau, MarĂ­a Del Mar AU - Riva, Alberto AU - Hartley, Stephen W. AU - Sedgewick, Amanda E. AU - Doria, Alessandro AU - Montano, Monty AU - Melista, Efthymia AU - Terry, Dellara AU - Perls, Thomas T. AU - Steinberg, Martin H. AU - Baldwin, Clinton T. PY - 2008 SN - 1471-2156 UR - http://hdl.handle.net/10481/31188 AB - [Background] One of the challenges of the analysis of pooling-based genome wide association studies is to identify authentic associations among potentially thousands of false positive associations. [Results] We present a hierarchical and... LA - eng PB - Biomed Central KW - Bayes theorem KW - Computational biology KW - DNA KW - Fetal hemoglobin KW - Gene frequency KW - Genetic markers KW - Genome KW - Genotype KW - Linkage disequilibrium KW - Sensitivity and specificity TI - A hierarchical and modular approach to the discovery of robust associations in genome-wide association studies from pooled DNA samples ER -