TY - JOUR AU - Vera Ramírez, Laura AU - Sánchez Rovira, Pedro AU - Ramírez Tortosa, César Luis AU - Quiles Morales, José Luis AU - Ramírez Tortosa, María Carmen AU - Lorente Acosta, José Antonio PY - 2013 SN - 1932-6203 UR - http://hdl.handle.net/10481/30790 AB - Background Distant recurrences after antineoplastic treatment remain a serious problem for breast cancer clinical management, which threats patients’ life. Systemic therapy is administered to eradicate cancer cells from the organism, both at the... AB - Methods/Findings To identify key molecules and signaling pathways which drive breast cancer chemoresistance we performed gene expression analysis before and after anthracycline and taxane-based chemotherapy and compared the results between... AB - Conclusions These data identify a set of key molecular pathways selectively up-regulated in post-chemotherapy cancer cells, which may become appropriate targets for the development of future directed therapies against breast cancer. LA - eng PB - Public Library of Science (PLOS) KW - Breast cancer KW - Cancer stem cells KW - Cancer treatment KW - Chemotherapy KW - Gene expression KW - Gene targeting KW - Genetic networks KW - Microarrays TI - Transcriptional Shift Identifies a Set of Genes Driving Breast Cancer Chemoresistance ER -