TY  - JOUR 
AU  - Pitcher, Mark H.
AU  - Price, Theodore J.
AU  - Entrena Fernández, José Manuel
AU  - Cervero, Fernando
PY  - 2007
SN  - 1744-8069
UR  - http://hdl.handle.net/10481/30785
AB  - Background
The Na+, K+, 2Cl- type I cotransporter (NKCC1) and TRPV1 receptors, at the level of the dorsal horn, have been implicated in mediating allodynia in response to an inflammatory insult. The NKCC1 cotransporter regulates intracellular [Cl-]...
AB  - Results
Here we have tested the role of spinal NKCC1 cotransporters and TRPV1 receptors in referred allodynia in a model of visceral hyperalgesia in mice. Intrathecal (IT) injection of the NKCC1 inhibitor bumetanide (BUM, 1 nmol) inhibited referred,...
AB  - Conclusion
Our findings indicate that spinal NKCC1 and TRPV1 are critical for referred allodynia mediated by a painful visceral stimulus. Moreover, they suggest that endogenous TRPV1 agonists, released in the CNS in painful conditions, might...
LA  - eng
PB  - Biomed Central
KW  - Abdomen
KW  - Aminobutyrates
KW  - Capsaicin
KW  - Pain
KW  - Soidum potassium chloride symporter inhibitors
KW  - TRPV cation channels
TI  - Spinal NKCC1 blockade inhibits TRPV1-dependent referred allodynia
ER  -