TY  - JOUR 
AU  - Zhao, Jing
AU  - Yuan, Guanglu
AU  - Cendán Martínez, Cruz Miguel
AU  - Nassar, Mohammed A.
AU  - Lagerström, Malin C.
AU  - Kullander, Klas
AU  - Gavazzi, Isabella
AU  - Wood, John N.
PY  - 2010
SN  - 1744-8069
UR  - http://hdl.handle.net/10481/30784
AB  - Background
EphB receptors and their ephrin-B ligands play an important role in nervous system development, as well as synapse formation and plasticity in the adult brain. Recent studies show that intrathecal treatment with EphB-receptor activator...
AB  - Results
The ephrin-B2 CKO mice were healthy with no sensory neuron loss. However, pain-related behavior was substantially altered. Although acute pain behavior and motor co-ordination were normal, inflammatory pain was attenuated in ephrin-B2 mutant...
AB  - Conclusions
Presynaptic ephrin-B2 expression thus plays an important role in regulating inflammatory pain through the regulation of synaptic plasticity in the dorsal horn and is also involved in the pathogenesis of some types of neuropathic pain.
LA  - eng
PB  - Biomed Central
KW  - Activatin transcription factor
KW  - Acute disease
KW  - Cell survival
KW  - Ephrin-B2
KW  - Exons
KW  - Ganglia
KW  - Inflammation
KW  - Neuralgia
KW  - Neurons
KW  - Spinal cord
TI  - Nociceptor-expressed ephrin-B2 regulates inflammatory and neuropathic pain
ER  -