TY - JOUR AU - Lavarino, Cinzia AU - Cheung, Nai-Kong V. AU - García, Idoia AU - Domenech, Gema AU - Torres, Carmen de AU - Alaminos Mingorance, Miguel AU - Ríos, José AU - Gerald, William L. AU - Kushner, Brian AU - LaQuaglia, Mike AU - Mora, Jaume PY - 2009 SN - 1471-2407 UR - http://hdl.handle.net/10481/30774 AB - Background: Neuroblastoma (NB) tumours have the highest incidence of spontaneous remission, especially among the stage 4s NB subgroup affecting infants. Clinical distinction of stage 4s from lethal stage 4 can be difficult, but critical for... AB - Methods: Thirty-five NB tumours from patients diagnosed at < 18 months (25 stage 4 and 10 stage 4s), were evaluated by allelic and gene expression analyses. AB - Results: All stage 4s patients underwent spontaneous remission, only 48% stage 4 patients survived despite combined modality therapy. Stage 4 tumours were 90% near-diploid/tetraploid, 44% MYCN amplified, 77% had 1p LOH (50% 1p36), 23% 11q and/or 14q... AB - Conclusion: Specific chromosomal aberrations are associated with distinct gene expression profiles which characterize spontaneously regressing or aggressive infant NB, providing the biological basis for the distinct clinical behaviour. LA - eng PB - Biomed Central KW - Chromosome aberrations KW - Gene expression profiling KW - Neoplastic KW - Neoplasm staging KW - Neoplastic processes KW - Neuroblastoma TI - Specific gene expression profiles and chromosomal abnormalities are associated with infant disseminated neuroblastoma ER -