TY  - JOUR 
AU  - Jiménez-Medina, Eva
AU  - Berruguilla, Enrique
AU  - Romero García, Irene
AU  - Algarra López, Ignacio
AU  - Collado, Antonia
AU  - Garrido Torres-Puchol, Federico
AU  - García Lora, Ángel Miguel
PY  - 2008
SN  - 1471-2407
UR  - http://hdl.handle.net/10481/29165
AB  - Background
Protein-bound polysaccharide (PSK) is derived from the CM-101 strain of the fungus Coriolus versicolor and has shown anticancer activity in vitro and in in vivo experimental models and human cancers. Several randomized clinical trials have...
AB  - Methods
The in vitro cytotoxic anti-tumour activity of PSK has been evaluated in various tumour cell lines derived from leukaemias, melanomas, fibrosarcomas and cervix, lung, pancreas and gastric cancers. Tumour cell proliferation in vitro was...
AB  - Results
PSK showed in vitro inhibition of tumour cell proliferation as measured by BrdU incorporation and viable cell count. The inhibition ranged from 22 to 84%. Inhibition mechanisms were identified as cell cycle arrest, with cell accumulation in...
AB  - Conclusion
These results indicate that PSK has cytotoxic activity in vitro on tumour cell lines. This new cytotoxic activity of PSK on tumour cells is independent of its previously described immunomodulatory activity on NK cells.
LA  - eng
PB  - Biomed Central
KW  - Apoptosis
KW  - Cell cycle
KW  - Drug screening assays
KW  - Fungal proteins
KW  - HeLa cells
KW  - Immunologic factors
KW  - Jurkat cells
KW  - Lymphocytes
KW  - Melanoma
KW  - Polysaccharides
KW  - Proteoglycans
TI  - The immunomodulator PSK induces in vitro cytotoxic activity in tumour cell lines via arrest of cell cycle and induction of apoptosis
ER  -