TY - JOUR AU - García Alcalde, Fernando AU - Blanco Morón, Armando AU - Shepherd, Adrian J. PY - 2010 SN - 1471-2105 UR - http://hdl.handle.net/10481/28495 AB - Background Transcription factors (TFs) control transcription by binding to specific regions of DNA called transcription factor binding sites (TFBSs). The identification of TFBSs is a crucial problem in computational biology and includes the subtask... AB - Results We propose SCintuit, a new scoring method for measuring sequence-motif affinity based on IFS theory. Unlike existing methods that consider dependencies between positions, SCintuit is designed to prevent overestimation of less conserved... AB - Conclusions The results show that SCintuit improves the prediction quality for TFs of the existing approaches without compromising sensitivity. In addition, we show how SCintuit can be successfully applied to real research problems. In this study the... LA - eng PB - Biomed Central KW - Algorithms KW - Computational biology KW - DNA KW - Regulatory elements KW - Transcription factors KW - Chemistry KW - Metabolism TI - An intuitionistic approach to scoring DNA sequences against transcription factor binding site motifs DO - 10.1186/1471-2105-11-551 ER -