Physical Activity, Gut Microbiota, and Genetic Background for Children and Adolescents with Autism Spectrum Disorder Plaza Díaz, Julio Solís Urra, Patricio Children Autism spectrum disorder Intestinal microbiota Physical activity Genetics It is estimated that one in 100 children worldwide has been diagnosed with autism spectrum disorder (ASD). Children with ASD frequently suffer from gut dysbiosis and gastrointestinal issues, findings which possibly play a role in the pathogenesis and/or severity of their condition. Physical activity may have a positive effect on the composition of the intestinal microbiota of healthy adults. However, the effect of exercise both on the gastrointestinal problems and intestinal microbiota (and thus possibly on ASD) itself in affected children is unknown. In terms of understanding the physiopathology and manifestations of ASD, analysis of the gut–brain axis holds some promise. Here, we discuss the physiopathology of ASD in terms of genetics and microbiota composition, and how physical activity may be a promising non-pharmaceutical approach to improve ASDrelated symptoms. 2023-01-16T08:51:16Z 2023-01-16T08:51:16Z 2022-11-27 info:eu-repo/semantics/article Plaza-Diaz, J... [et al.]. Physical Activity, Gut Microbiota, and Genetic Background for Children and Adolescents with Autism Spectrum Disorder. Children 2022, 9, 1834. [https://doi.org/10.3390/children9121834] https://hdl.handle.net/10481/79010 10.3390/children9121834 eng http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Atribución 4.0 Internacional MDPI