Wilson disease and psychiatric symptoms: A brief case report Guerrero Jiménez, Margarita Carrillo de Albornoz Calahorro, Carmen Maura Gutiérrez Rojas, Luis Wilson disease (WD) is an uncommon recessive genetic disorder affecting copper metabolism. Cardiac, neurological, hepatic and renal manifestations are well defined, nevertheless approximately 30% of patients debut with neuropsychiatric symptoms. These psychiatric alterations resulting from the accumulation of this heavy metal in the basal ganglia are some how less specific. We present a short review of psychiatric symptoms of WD and describe a case of a 37-year-old woman diagnosed with WD who presented neuropsychiatric symptoms and had a consequent delay in diagnosis and causal treatment. Patients who develop WD starting with a predominance of neuropsychiatric symptoms tend to manifest hepatic symptoms later, therefore have a longer delay of diagnosis and a poorer outcome than patients with hepatic symptoms. An early diagnosis of WD can avoid irreversible neurological damage. 2019-10-24T10:58:07Z 2019-10-24T10:58:07Z 2019 info:eu-repo/semantics/article Guerrero-Jiménez M, Carrillo de Albornoz Calahorro CM, Gutierrez Rojas L. Wilson disease and psychiatric symptoms: A brief case report. General Psychiatry 2019;32:e100066 [doi: 10.1136/gpsych-2019-100066] http://hdl.handle.net/10481/57498 10.1136/gpsych-2019-100066 eng http://creativecommons.org/licenses/by-nc/3.0/es/ info:eu-repo/semantics/openAccess Atribución-NoComercial 3.0 España BMJ