Development of Biotransamination Reactions towards the 3,4-Dihydro-2H-1,5-benzoxathiepin-3- amine Enantiomers González-Martínez, Daniel Fernández-Sáez, Nerea Cativiela, Carlos Campos, Joaquín M. Gotor-Fernández, Vicente Amine transaminases Asymmetric synthesis Benzoxathiepins Biocatalysis Biotransamination Stereoselective synthesis The stereoselective synthesis of chiral amines is an appealing task nowadays. In this context, biocatalysis plays a crucial role due to the straightforward conversion of prochiral and racemic ketones into enantiopure amines by means of a series of enzyme classes such as amine dehydrogenases, imine reductases, reductive aminases and amine transaminases. In particular, the stereoselective synthesis of 1,5-benzoxathiepin-3-amines have attracted particular attention since they possess remarkable biological profiles; however, their access through biocatalytic methods is unexplored. Amine transaminases are applied herein in the biotransamination of 3,4-dihydro-2H-1,5-benzoxathiepin-3-one, finding suitable enzymes for accessing both target amine enantiomers in high conversion and enantiomeric excess values. Biotransamination experiments have been analysed, trying to optimise the reaction conditions in terms of enzyme loading, temperature and reaction times. 2019-04-29T12:36:30Z 2019-04-29T12:36:30Z 2018-10-19 info:eu-repo/semantics/article González-Martínez, D. [et al.]. Development of Biotransamination Reactions towards the 3,4-Dihydro-2H-1,5-benzoxathiepin-3- amine Enantiomers. Catalysts 2018, 8, 470; doi:10.3390/catal8100470 2073-4344 http://hdl.handle.net/10481/55529 eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España MDPI