Cooperativity and flexibility in enzyme evolution Pabis, Anna Risso, Valeria Alejandra Sánchez Ruiz, José Manuel Kamerlin, Shina CL Enzymes are flexible catalysts, and there has been substantial discussion about the extent to which this flexibility contributes to their catalytic efficiency. What has been significantly less discussed is the extent to which this flexibility contributes to their evolvability. Despite this, recent years have seen an increasing number of both experimental and computational studies that demonstrate that cooperativity and flexibility play significant roles in enzyme innovation. This review covers key developments in the field that emphasize the importance of enzyme dynamics not just to the evolution of new enzyme function(s), but also as a property that can be harnessed in the design of new artificial enzymes. 2018-07-11T08:14:23Z 2018-07-11T08:14:23Z 2017-11-12 info:eu-repo/semantics/article Pabis, Anna; et. al. Cooperativity and flexibility in enzyme evolution. Current Opinion in Structural Biology 2018, 48:83–92 [http://hdl.handle.net/10481/52221] 0959-440X http://hdl.handle.net/10481/52221 10.1016/j.sbi.2017.10.020 eng info:eu-repo/grantAgreement/EC/FP7/306474 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España Elsevier B. V.