<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/51305">
      <dc:title>Anticancer Applications of Nanostructured Silica-Based Materials Functionalized with Titanocene Derivatives: Induction of Cell Death Mechanism through TNFR1 Modulation</dc:title>
      <dc:creator>Gómez-Ruiz, Santiago</dc:creator>
      <dc:creator>García-Peñas, Alberto</dc:creator>
      <dc:creator>Prashar, Sanjiv</dc:creator>
      <dc:creator>Rodríguez Diéguez, Antonio</dc:creator>
      <dc:creator>Fischer-Fodor, Eva</dc:creator>
      <dc:subject>Nanostructured silica</dc:subject>
      <dc:subject>Titanocene</dc:subject>
      <dc:subject>Cytotoxicity</dc:subject>
      <dc:subject>Anticancer</dc:subject>
      <dc:subject>Tumor necrosis factor</dc:subject>
      <dc:subject>TNFR1 modulation</dc:subject>
      <dc:description>A series of cytotoxic titanocene derivatives have been immobilized onto nanostructured silica-based materials using two different synthetic routes, namely, (i) a simple grafting protocol via protonolysis of the Ti-Cl bond; and (ii) a tethering method by elimination of ethanol using triethoxysilyl moieties of thiolato ligands attached to titanium. The resulting nanostructured systems have been characterized by different techniques such as XRD, XRF, DR-UV, BET, SEM, and TEM, observing the incorporation of the titanocene derivatives onto the nanostructured silica and slight changes in the textural features of the materials after functionalization with the metallodrugs. A complete biological study has been carried out using the synthesized materials exhibiting moderate cytotoxicity in vitro against three human hepatic carcinoma (HepG2, SK-Hep-1, Hep3B) and three human colon carcinomas (DLD-1, HT-29, COLO320) and very low cytotoxicity against normal cell lines. In addition, the cells' metabolic activity was modified by a 24-h exposure in a dose-dependent manner. Despite not having a significant effect on TNFα or the proinflammatory interleukin 1α secretion, the materials strongly modulated tumor necrosis factor (TNF) signaling, even at sub-cytotoxic concentrations. This is achieved mainly by upregulation of the TNFR1 receptor production, something which has not previously been observed for these systems.</dc:description>
      <dc:date>2018-06-08T10:30:02Z</dc:date>
      <dc:date>2018-06-08T10:30:02Z</dc:date>
      <dc:date>2018-01-31</dc:date>
      <dc:type>info:eu-repo/semantics/article</dc:type>
      <dc:identifier>Gómez-Ruiz, Santiago; et. al. Anticancer Applications of Nanostructured Silica-Based Materials Functionalized with Titanocene Derivatives: Induction of Cell Death Mechanism through TNFR1 Modulation. Materials 2018, 11, 224 [http://hdl.handle.net/10481/51305]</dc:identifier>
      <dc:identifier>http://hdl.handle.net/10481/51305</dc:identifier>
      <dc:identifier>10.3390/ma11020224</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by/3.0/es/</dc:rights>
      <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
      <dc:rights>Atribución 3.0 España</dc:rights>
      <dc:publisher>MDPI</dc:publisher>
   </ow:Publication>
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