Oral Mucositis: Melatonin Gel an Effective New Treatment Moneim, Ahmed E. Abdel Guerra Librero Rite, Ana Florido Ruiz, Javier Shen, Ying-Qiang Fernández-Gil, Beatriz Acuña Castroviejo, Darío Escames Rosa, Germaine Mucositis Radiotherapy Chemotherapy Pathophysiology Management Melatonin The current treatment for cervico-facial cancer involves radio and/or chemotherapy. Unfortunately, cancer therapies can lead to local and systemic complications such as mucositis, which is the most common dose-dependent complication in the oral cavity and gastrointestinal tract. Mucositis can cause a considerably reduced quality of life in cancer patients already suffering from physical and psychological exhaustion. However, the role of melatonin in the treatment of mucositis has recently been investigated, and offers an effective alternative therapy in the prevention and/or management of radio and/or chemotherapy-induced mucositis. This review focuses on the pathobiology and management of mucositis in order to improve the quality of cancer patients’ lives. 2018-01-23T10:27:49Z 2018-01-23T10:27:49Z 2017 info:eu-repo/semantics/article Moneim, A.E.A.; et al. Oral Mucositis: Melatonin Gel an Effective New Treatment. International Journal of Molecular Sciences, 18(5): 1003 (2017). [http://hdl.handle.net/10481/49107] 1422-0067 http://hdl.handle.net/10481/49107 10.3390/ijms18051003 eng http://creativecommons.org/licenses/by-nc-nd/3.0/ info:eu-repo/semantics/openAccess Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License MDPI