Nuevas perspectivas en el tratamiento de la Leishmaniosis: Evaluación de derivados hidroxámicos y (-)-α-bisabolol Corpas López, Victoriano Martín Sánchez, Joaquina Morillas Márquez, Francisco Universidad de Granada. Departamento de Parasitología Universidad de Granada. Leishmaniosis Parásitos Tratamiento Hidroxámicos Bisabolol España The aim of this work was to put forward new treatment perspectives for leishmaniasis. In order to accomplish it, the objectives of the study were to screen new synthetic HDAC inhibitors and the natural compound (-)-α-bisabolol, to characterize HDAC enzymes in Leishmania, to get an insight into the mechanism of action of (-)-α-bisabolol, to evaluate in vivo the most active structures; and finally, to assess the potential effectiveness and safety of these molecules in a pilot clinical trial involving dogs with canine leishmaniasis (CanL) naturally acquired. 2016-07-21T09:35:11Z 2016-07-21T09:35:11Z 2016 2015-12-21 info:eu-repo/semantics/doctoralThesis Corpas López, V. Nuevas perspectivas en el tratamiento de la Leishmaniosis: Evaluación de derivados hidroxámicos y (-)-α-bisabolol. Granada: Universidad de Granada, 2016. [http://hdl.handle.net/10481/42208] 9788491254799 http://hdl.handle.net/10481/42208 spa http://creativecommons.org/licenses/by-nc-nd/3.0/ info:eu-repo/semantics/openAccess Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License Universidad de Granada