Tissue Specific Promoters in Colorectal Cancer Rama Ballesteros, Ana Rosa Aguilera, A. Melguizo Alonso, Consolación Caba Pérez, Octavio Prados Salazar, José Carlos Colorectal cancer Chemotherapy Gene therapy Review Colorectal carcinoma Treatment Colorectal carcinoma is the third most prevalent cancer in the world. In the most advanced stages, the use of chemotherapy induces a poor response and is usually accompanied by other tissue damage. Significant progress based on suicide gene therapy has demonstrated that it may potentiate the classical cytotoxic effects in colorectal cancer. The inconvenience still rests with the targeting and the specificity efficiency. The main target of gene therapy is to achieve an effective vehicle to hand over therapeutic genes safely into specific cells. One possibility is the use of tumor-specific promoters overexpressed in cancers. They could induce a specific expression of therapeutic genes in a given tumor, increasing their localized activity. Several promoters have been assayed into direct suicide genes to cancer cells. This review discusses the current status of specific tumor-promoters and their great potential in colorectal carcinoma treatment. 2016-01-22T08:55:15Z 2016-01-22T08:55:15Z 2015 info:eu-repo/semantics/article Rama Ballesteros, A.R.; et al. Tissue Specific Promoters in Colorectal Cancer. Disease Markers, 2015: 390161 (2015). [http://hdl.handle.net/10481/39551] 0278-0240 1875-8630 http://hdl.handle.net/10481/39551 10.1155/2015/390161 eng http://creativecommons.org/licenses/by-nc-nd/3.0/ info:eu-repo/semantics/openAccess Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License Hindawi Publishing Corporation